Zimmer Publications

Key Publications

Uzel K, Kato S, Zimmer M. (2022). A set of hub neurons and non-local connectivity features support global brain dynamics in C. elegans. Current Biology. Jul 1:S0960-9822(22)01001-6. doi: doi.org/10.1016/j.cub.2022.06.039. Epub ahead of print. PMID: 35809568.

Riedl J, Zimmer M. (2022). Tyraminergic corollary discharge filters reafferent perception in a chemosensory neuron. Current Biology. Jun 3:S0960-9822(22)00854-5. https://doi.org/10.1016/j.cub.2022.05.051. Epub ahead of print.

Kaplan HS, Zimmer M (2020). Brain-wide representations of ongoing behavior: a universal principle? Current Opinion in Neurobiology. 64, 60–69. http://doi.org/10.1016/j.conb.2020.02.008

Kaplan HS, Salazar Thula O, Khoss N, Zimmer M (2020). Nested neuronal dynamics orchestrate a behavioral hierarchy across timescales. Neuron. 105(3), 562–576.e9. http://doi.org/10.1016/j.neuron.2019.10.037

Skora S, Mende F, Zimmer M (2018). Energy scarcity promotes a brain-wide sleep state modulated by insulin signaling in C. elegans. Cell Reports Jan 23;22(4):953-966. https://doi.org/10.1016/j.celrep.2017.12.091

Nichols ALA, Eichler T, Latham R, Zimmer M (2017). A global brain state underlies C. elegans sleep behavior. Science 356, eaam6851. https://doi.org/10.1126/science.aam6851

Hums I, Riedl J, Mende F, Kato S, Kaplan HS, Latham R, Sonntag M, Traunmüller T, and Zimmer M (2016). Regulation of two motor patterns enables the gradual adjustment of locomotion strategy in Caenorhabditis elegans. eLife 2016;5:e14116. https://doi.org/10.7554/eLife.14116

Kato S^*, Kaplan HS^*, Schrödel T^*, Skora S, Lindsay TH, Yemini E, Lockery S, Zimmer M (2015). Global Brain Dynamics Embed the Motor Command Sequence of Caenorhabditis elegans. Cell, 163(3), 656–669. https://doi.org/10.1016/j.cell.2015.09.034* Authors with equal contribution

Schrödel T^*, Prevedel R^*, Aumayr K, Zimmer M⁺ & Vaziri A⁺ (2013). Brain-wide 3D imaging of neuronal activity in Caenorhabditis elegans with sculpted light. Nature Methods Oct;10(10):1013-20. https://doi.org/10.1038/nmeth.2637 + Corresponding authors, * authors with equal contribution

Zimmer M, Gray JM, Pokala N, Chang AJ, Karow DS, Marletta MA, Hudson ML, Morton DB, Chronis N & Bargmann CI (2009). Neurons Detect Increases and Decreases in Oxygen Levels Using Distinct Guanylate Cyclases. Neuron Mar 26; 61(6): 865-879. https://doi.org/10.1016/j.neuron.2009.02.013

Chronis N, Zimmer M, Bargmann CI (2007). Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans. Nature Methods Sep; 4(9): 727-31. https://doi.org/10.1038/nmeth1075

Zimmer M, Palmer A, Köhler J, Klein R (2003). EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nature Cell Biology Oct; 5(10): 869-878. https://doi.org/10.1038/ncb1045

Palmer A*, Zimmer M*, Erdmann KS, Eulenburg V, Porthin A, Heumann R, Deutsch U, Klein R (2002). EphrinB phosphorylation and reverse signaling: Regulation by Src kinases and PTP-BL phosphatase. Molecular Cell Apr; 9(4): 725-37. https://doi.org/10.1016/S1097-2765(02)00488-4
* Authors with equal contribution

Full Publication List

Uzel K, Kato S, Zimmer M. (2022). A set of hub neurons and non-local connectivity features support global brain dynamics in C. elegans. Current Biology. Jul 1:S0960-9822(22)01001-6. doi: https://doi.org/10.1016/j.cub.2022.06.039. Epub ahead of print. PMID: 35809568.

Lev I, Zimmer M (2022). Predator-prey interactions: Strategic biting. Current Biology. Apr 25;32(8):R367-R370. Preview article. doi: 10.1016/j.cub.2022.03.026.

Zimmer M. (2021). Insect locomotion: Flies show you how to stay on course. Current Biology. Oct 25;31(20):R1395-R1397. Preview article. doi: 10.1016/j.cub.2021.09.015.

Emmons SW, Yemini E, Zimmer M. (2021). Methods for analyzing neuronal structure and activity in Caenorhabditis elegans. Genetics. doi.org/10.1093/genetics/iyab072

Fieseler C, Zimmer, M, Kutz, JN. (2020). Unsupervised learning of control signals and their encodings in Caenorhabditis elegans whole-brain recordings. Journal of the Royal Society Interface, 17(173), 20200459. http://doi.org/10.1098/rsif.2020.0459

Kaplan HS, Zimmer M (2020). Brain-wide representations of ongoing behavior: a universal principle? Current Opinion in Neurobiology. 64, 60–69. http://doi.org/10.1016/j.conb.2020.02.008

Uzel K., Zimmer M (2019). Imaging the Emergence of Behavior. Cell 179(2), 285–286. Preview article. http://doi.org/10.1016/j.cell.2019.09.006

Lechner M, Hasani R, Zimmer M, Henzinger TA and Grosu R (2019). Designing Worm-inspired Neural Networks for Interpretable Robotic Control. International Conference on Robotics and Automation (ICRA). 2019, pp. 87-94, doi: 10.1109/ICRA.2019.8793840.

Kaplan HS, Nichols ALA, Zimmer M (2018). Sensorimotor integration in C. elegans: a reappraisal towards dynamic and distributed computations. Philos Trans R Soc Lond B Biol Sci. Sep 10;373(1758). pii: 20170371. https://doi.org/10.1098/rstb.2017.0371

Kaplan HS, Zimmer M (2018). Sensorimotor Integration for Decision Making: How the Worm Steers. Neuron. 2018 Jan 17;97(2):258-260. Preview article. https://doi.org/10.1016/j.neuron.2017.12.042

Rojo Romanos T⁺, Ng L, Zimmer M⁺, Pocock R⁺ (2018). Behavioral Assays to Study Oxygen and Carbon Dioxide Sensing in Caenorhabditis elegans. Bio-Protocol, 8(1). http://doi.org/10.21769/BioProtoc.2679 + Corresponding authors

Rouse T, Aubry G, Cho Y, Zimmer M, Lu H (2018). A programmable platform for sub-second multichemical dynamic stimulation and neuronal functional imaging in C. elegans. Lab Chip, Jan 9. (Epub ahead of print). https://doi.org/10.1039/c7lc01116d

Nichols ALA, Eichler T, Latham R, Zimmer M (2017). A global brain state underlies C. elegans sleep behavior. Science 356, eaam6851. https://doi.org/10.1126/science.aam6851

Jang H, Levy S, Flavell SW, Mende F, Latham R, Zimmer M and Bargmann CI (2017). Dissection of neuronal gap junction circuits that regulate social behavior in Caenorhabditis elegans. P.N.A.S., 201621274–10. https://doi.org/10.1073/pnas.1621274114

Drexel T, Mahofsky K, Latham R, Zimmer M, Cochella L (2016). Neuron type-specific miRNA represses two broadly expressed genes to modulate an avoidance behavior in C. elegans. Genes & Development, 30(18), 2042–2047. https://doi.org/10.1101/gad.287904.116

Witham E, Comunian C, Ratanpal H, Skora S, Zimmer M, & Srinivasan S (2016). C. elegans Body Cavity Neurons Are Homeostatic Sensors that Integrate Fluctuations in Oxygen Availability and Internal Nutrient Reserves. Cell Reports. 14(7), 1641–1654. https://doi.org/10.1016/j.celrep.2016.01.052

Moreno E, McGaughran A, Rödelsperger C, Zimmer M, & Sommer RJ (2016). Oxygen-induced social behaviours in Pristionchus pacificushave a distinct evolutionary history and genetic regulation from Caenorhabditis elegans. Proceedings of the Royal Society B: Biological Sciences, 283(1825), 20152263–9. https://doi.org/10.1098/rspb.2015.2263

Yapici N, Zimmer M, & Domingos AI (2014). Cellular and molecular basis of decision-making. EMBO Reports, 15(10), 1023–1035. Review. https://doi.org/10.15252/embr.201438993

Prevedel R, Yoon, YG, Hoffmann M, Pak N, Wetzstein G, Kato S, Schrödel T, Raskar R, Zimmer M, Boyden ES, Vaziri A (2014). Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy. Nature Methods 11(7), 727–730. https://doi.org/10.1038/nmeth.2964

Skora S, and Zimmer M (2013). Life(span) in balance: oxygen fuels a sophisticated neural network for lifespan homeostasis in C. elegans. Embo J 32, 1499–1501. Preview. https://doi.org/10.1038/emboj.2013.101

Gramstrup Petersen J, Rojo Romanos T, Juozaityte V, Redo Riveiro A, Hums I, Traunmüller L, Zimmer M, and Pocock, R (2013). EGL-13/SoxD Specifies Distinct O₂ and CO₂ Sensory Neuron Fates in Caenorhabditis elegans. PLoS Genet May;9(5):e1003511. https://doi.org/10.1371/journal.pgen.1003511

McGrath PT, Rockman MV, Zimmer M, Macosko EZ, Jang H, Kruglyak L, and Bargmann CI (2009). Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory behaviors. Neuron Mar 12; 61(5): 692-699. https://doi.org/10.1016/j.neuron.2009.02.012

Essmann CL, Martinez E, Geiger JC, Zimmer M, Traut MH, Stein V, Klein R, Acker-Palmer, A (2008). Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Nature Neuroscience Sep; 11(9): 1035-43. https://doi.org/10.1038/nn.2171

Kullander K, Croll SD, Zimmer M, Pan L, McClain J, Hughes V, Zabski S, DeChiara TM, Klein R, Yancopoulos GD, Gale NW (2001). Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes & Development. Apr 1; 15(7): 877-88. https://doi.org/10.1101/gad.868901

Watty A, Neubauer G, Dreger M, Zimmer M, Wilm M, Burden SJ (2000). The in vitro and in vivo phosphotyrosine map of activated MuSK. Proc. Natl. Acad. Sci. U S A. Apr 25; 97(9): 4585-90. https://doi.org/10.1073/pnas.080061997