Key publications


  • Zimmermann B, Montenegro JD, Robb SMC, Genikhovich G, Fropf WJ, Weilguny L, He S, Chen S, Lovegrove-Walsh J, Hill EM, Ragkousi K, Praher D, Fredman D, Schultz D, Moran Y, Simakov O, Gibson MC*, Technau U.* (2023).Topological structures and conservation of synteny in sea anemone genomes. Nature Comm, in press. bioRxiv 2020.10.30.359448; doi.org/10.1101/2020.10.30.359448
  • Cole AG, Jahnel SM, Kaul S, Steger J, Hagauer, J,  Taudes E, Zimmerman B, Reischl R, Denner A, Ferrer Murguia P, Steinmetz P, Technau U. (2023). Muscle cell-type diversification is driven by bHLH transcription factor expansion and facilitated by extensive gene duplications. Nature Comm. 14(1):1747. doi: 10.1038/s41467-023-37220-6.
  • Schwaiger M, Andrikou C, Dnyansagar R, Ferrer Murguia P, Paganos P, Voronov D, Zimmermann B, Lebedeva T, Schmidt HA, Genikhovich, G, Benvenuto G, Arnone MI*, Technau U.* (2022). An ancestral Wnt-Brachyury feedback loop in axial patterning and recruitment of mesoderm-determining target genes. Nature Ecol. Evol. 6(12):1921-1939. doi.org/10.1038/s41559-022-01905-w.
  • Steger J, Cole AG, Denner A, Lebedeva T, Genikhovich G, Ries A, Reischl R, Taudes E, Lassnig M, Technau U.* (2022). Single cell transcriptomics identifies conserved regulators of neuroglandular lineages. Cell Reports, 40(12):111370. doi: 10.1016/j.celrep.2022.111370.
  • Pukhlyakova, E, Aman, A and Technau, U (2019) b-catenin dependent mechanotransduction dates back to the common ancestor of Cnidaria and Bilateria. Proc Natl Acad Sci U S A, 115(24):6231-6236. doi: 10.1073/pnas.1713682115. 
  • Kirillova, A, Genikhovich, G, Pukhlyakova, E, Demilly, A, Kraus, Y, Technau, U (2018). Germ layer commitment and axis formation in sea anemone embryonic cell aggregates. Proc Natl Acad Sci U S A, 115, 1813-1818.
  • Steinmetz, P.R.H.*, Aman, A., Kraus, J.E.M., Technau, U. (2017). Gut-like ectodermal tissue in a sea anemone challenges germ layer homology. Nature Ecol Evol. DOI: 10.1038/s41559-017-0285-5.
  • Cole AG,* Jahnel SM, Kaul S, Steger J, Hagauer, J, Taudes E, Zimmerman B, Reischl R, Denner A, Ferrer Murguia P, Steinmetz P, Technau U.* (2023). Muscle cell-type diversification is driven by bHLH transcription factor expansion and facilitated by extensive gene duplications. Nature Comm. 14, 1747. PMID: 36990990
  • Schwaiger M, Andrikou C, Dnyansagar R, Ferrer Murguia P, Paganos P, Voronov D, Zimmermann B, Lebedeva T, Schmidt HA, Genikhovich, G, Benvenuto G, Arnone MI*, Technau U.* (2022). An ancestral Wnt-Brachyury feedback loop in axial patterning and recruitment of mesoderm-determining target genes. Nature Ecol. Evol.doi.org/10.1038/s41559-022-01905-w.
  • Steger J, Cole AG, Denner A, Lebedeva T, Genikhovich G, Ries A, Reischl R, Taudes E, Lassnig M, Technau U.*(2022). Single cell transcriptomics identifies conserved regulators of neuroglandular lineages. Cell Reports, 40(12):111370. doi: 10.1016/j.celrep.2022.111370.
  • Kirillova, A, Genikhovich, G*, Pukhlyakova, E, Demilly, A, Kraus, Y*, Technau, U* (2018). Germ layer commitment and axis formation in sea anemone embryonic cell aggregates. Proc Natl Acad Sci U S A, 115, 1813-1818. PMID: 29440382
  • Moran, Y*, Agron, M, Praher, D and Technau, U* (2017). Evolution of plant and animal miRNAs. Nature Ecol Evol. 1:27. PMID: 28529980
  • Steinmetz, P.R.H.*, Aman, A., Kraus, J.E.M., Technau, U.* (2017). Gut-like ectodermal tissue in a sea anemone challenges germ layer homology. Nature Ecol Evol. 1(10):1535-1542. PMID: 29185520
  • Schwaiger, M., Schönauer, A., Rendeiro, A.F., Pribitzer, C., Schauer, A., Gilles, A.F., Schinko, J.B., Renfer, E., Fredman, D., and Technau, U.* (2014). Evolutionary conservation of the eumetazoan gene regulatory landscape. Genome Res. 24(4):639-50. PMID: 24642862
  • Steinmetz, P.R.H., Kraus, J.E.M., Larroux, C., Hammel, J.U., Amon-Hassenzahl, A., Houliston, E., Wörheide, G., Nickel, M., Degnan, B.M., and Technau, U.* (2012). Independent evolution of striated muscles in cnidarians and bilaterians. Nature, 487:231-4. PMID: 22763458. News and Views in the same issue. 
  • Putnam, N.H., Srivastava, M., Hellsten, U., Dirks, B., Chapman, J., Salamov, A., Terry, A., Shapiro, H., Lindquist, E., Kapitonov, V.V., Jurka, J., Genikhovich, G., Grigoriev, I.V., Lucas, S.M., Steele, R.E., Finnerty, J.R., Technau, U., Martindale, M.Q. and Rokshar, D.S. (2007). Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization. Science 317, 86-94. PMID: 17615350
  • Chourrout, D*., Delsuc, F., Chourrout, P., Edvardsen, R.B., Rentzsch, F., Renfer, E. Jensen, M.F., Zhu, B., de Jong, P., Steele, R.E. and Technau, U.* (2006). Minimal protohox cluster inferred from bilaterian and cnidarian Hox complements. Nature, 442, 684-687. PMID: 1690019

 

the full publication list is found under: https://scholar.google.at/citations?user=RtIvguIAAAAJ&hl=en

 

2022

2021

2020

  • da Fonseca RR, Couto A, Machado AM, Brejova B, Albertin CB, Silva F, Gardner P, Baril T, Hayward A, Campos A, Ribeiro ÂM, Barrio-Hernandez I, Hoving HJ, Tafur-Jimenez R, Chu C, Frazão B, Petersen B, Peñaloza F, Musacchia F, Alexander GC, et al . A draft genome sequence of the elusive giant squid, Architeuthis dux. Gigascience. 2020 Jan 1;9(1). pii: giz152. doi:10.1093/gigascience/giz152

 

2019

  • Drinnenberg IA, Berger F, Elsässer SJ, Andersen PR, Ausió J, Bickmore WA, Blackwell AR, Erwin DH, Gahan JM, Gaut BS, Harvey ZH, Henikoff S, Kao JY, Kurdistani SK, Lemos B, Levine MT, Luger K, Malik HS, Martín-Durán JM, Peichel CL, Renfree MB, Rutowicz K, Sarkies P, Schmitz RJ, Technau U, Thornton JW, Warnecke T, Wolfe KH. (2019). EvoChromo: towards a synthesis of chromatin biology and evolution. Development 146(19). pii: dev178962. doi: 10.1242/dev.178962.
  • Zimmermann B, Robert N, Technau U, Simakov O. (2019). Ancient animal genome architecture reflects cell type identities. Nature Evol. Evol. doi: 10.1038/s41559-019-0946-7.
  • Belcaid M, Casaburi G, McAnulty SJ, Schmidbaur H, Suria AM, Moriano-Gutierrez S, Pankey MS, Oakley TH, Kremer N, Koch EJ, Collins AJ, Nguyen H, Lek S, Goncharenko-Foster I, Minx P, Sodergren E, Weinstock G, Rokhsar DS, McFall-Ngai M, Simakov O, Foster JS, Nyholm SV. (2019) Symbiotic organs shaped by distinct modes of genome evolution in cephalopods. Proc Natl Acad Sci U S A.P 2019 Feb 19;116(8):3030-3035.

 

2018

 

2017

  • Bosch TC, Klimovich A, Domazet-Lošo T, Gründer S, Holstein TW, Jékely G, Miller DJ, Murillo-Rincon AP, Rentzsch F, Richards GS, Schröder K, Technau U, Yuste R. (2017) Back to the Basics: Cnidarians Start to Fire. Trends Neurosci. 2017 Feb;40(2):92-105. Review.

 

2016

 

2015 

  • Technau, U., Genikhovich, G.  and Kraus, J.E.M. (2015). Cnidaria. In: Evolutionary Developmental Biology of Invertebrates. Vol. 1, pp. 115-163. Editor: A. Wanninger. Springer, New York.

 

2014

 

2013

 

2012

 

2011

  • Moran Y, Genikhovich G, Gordon D, Wienkoop S, Zenkert C, Ozbek S, Technau U, Gurevitz M (2011) Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones. Proc Biol Sci. 2011 Nov 2.
  • Genikhovich G, Technau U (2011) Complex functions of Mef2 splice variants in the differentiation of endoderm and of a neuronal cell type in a sea anemone. Development. 2011 Nov;138(22):4911-9
  • Irimia M, Denuc A, Burguera D, Somorjai I, Martín-Durán JM, Genikhovich G, Jimenez-Delgado S, Technau U, Roy SW, Marfany G, Garcia-Fernàndez J (2011) Stepwise assembly of the Nova-regulated alternative splicing network in the vertebrate brain. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5319-24. Epub 2011 Mar 9
  • Technau U, Steele RE (2011) Evolutionary crossroads in developmental biology: Cnidaria. Development. 2011 Apr;138(8):1447-58. Epub 2011 Mar 9. Review

 

2010

  • Steele RE, David CN, Technau U (2010) A genomic view of 500 million years of cnidarian evolution. Trends Genet. 2010 Nov 1. 
  • Raible F, Steinmetz PRH (2010). Metazoan complexity. In: Introduction to Marine Genomics. Edited by Cock JM, Tessmar-Raible K, Boyen C., Viard F. Springer Dordrecht Heidelberg London New York.
  • Chapman JA, Kirkness EF, Simakov O, Hampson SE, Mitros T, Weinmaier T, Rattei T, Balasubramanian PG, Borman J, Busam D, Disbennett K, Pfannkoch C, Sumin N, Sutton GG, Viswanathan LD, Walenz B, Goodstein DM, Hellsten U, Kawashima T, Prochnik SE, Putnam NH, Shu S, Blumberg B, Dana CE, Gee L, Kibler DF, Law L, Lindgens D, Martinez DE, Peng J, Wigge PA, Bertulat B, Guder C, Nakamura Y, Ozbek S, Watanabe H, Khalturin K, Hemmrich G, Franke A, Augustin R, Fraune S, Hayakawa E, Hayakawa S, Hirose M, Hwang JS, Ikeo K, Nishimiya-Fujisawa C, Ogura A, Takahashi T, Steinmetz PR, Zhang X, Aufschnaiter R, Eder MK, Gorny AK, Salvenmoser W, Heimberg AM, Wheeler BM, Peterson KJ, Böttger A, Tischler P, Wolf A, Gojobori T, Remington KA, Strausberg RL, Venter JC, Technau U, Hobmayer B, Bosch TC, Holstein TW, Fujisawa T, Bode HR, David CN, Rokhsar DS, Steele RE (2010) The dynamic genome of Hydra. Nature. 2010 Mar 25;464(7288):592-6
  • Miller DJ, Technau U. (2010) Understanding the evolution of multicellularity: insights from basal metazoans. Bioessays. 2010 Feb;32(2):175-8
  • Renfer E, Amon-Hassenzahl A, Steinmetz PRH, Technau U (2010) A muscle-specific transgenic reporter line of the sea anemone Nematostella vectensis. PNAS 2010 Jan 5; 107:104-108
  • Genikhovich G, Technau U (2010) The starlet sea anemone Nematostella vectensis: an anthozoan model organism for studies in comparative genomics and functional evolutionary developmental biology. CSH Protoc. 2009 Sep;2009(9):pdb.emo129 
  • Genikhovich G, Technau U (2010) Bromodeoxyuridine labeling of S-phase nuclei in the starlet sea anemone Nematostella vectensis. CSH Protoc. 2009 Sep;2009(9):pdb.prot5284
  • Genikhovich G, Technau U (2010) Anti-acetylated tubulin antibody staining and phalloidin staining in the starlet sea anemone Nematostella vectensis. CSH Protoc. 2009 Sep;2009(9):pdb.prot5283
  • Genikhovich G, Technau U (2010) In situ hybridization of starlet sea anemone (Nematostella vectensis) embryos, larvae, and polyps. CSH Protoc. 2009 Sep;2009(9):pdb.prot5282
  • Genikhovich G, Technau U (2010) Induction of spawning in the starlet sea anemone Nematostella vectensis, in vitro fertilization of gametes, and dejellying of zygotes. CSH Protoc. 2009 Sep;2009(9):pdb.prot5281

 

2009

  • Saina M, Genikhovich G, Renfer E, Technau U (2009). BMPs and Chordin regulate patterning of the directive axis in a sea anemone. PNAS 2009 Nov 3; 106 (44): 18592-18597
  • Saina M, Technau U (2009). Characterization of myostatin/gdf8/11 in the starlet sea anemone Nematostella vectensis. J Exp Zool B Mol Dev Evol. 2009 Jun 16;312B(7):780-788
  • Egger B, Steinke D, Tarui H, De Mulder K, Arendt D, Borgonie G, Funayama N, Gschwentner R, Hartenstein V, Hobmayer B, Hooge M, Hrouda M, Ishida S, Kobayashi C, Kuales G, Nishimura O, Pfister D, Rieger R, Salvenmoser W, Smith J, Technau U, Tyler S, Agata K, Salzburger W, Ladurner P. (2009). To be or not to be a flatworm: the acoel controversy. PLoS ONE 4(5):e5502. 
  • Feta A, Do AT, Rentzsch F, Technau U, Kusche-Gullberg M (2008) Molecular analysis of heparan sulphate biosynthetic enzyme machinery and characterization of heparan sulphate structure in Nematostella vectensis. Biochem J. 2009 Jan 26
  • Yin Y, Bangs F, Paton IR, Prescott A, James J, Davey MG, Whitley P, Genikhovich G, Technau U, Burt DW, Tickle C (2008). The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation. Development. 2009 Feb;136(4):655-64.

 

2008

  • Shinzato C, Iguchi A, Hayward DC, Technau U, Ball EE, Miller DJ (2008). Sox genes in the coral Acropora millepora: divergent expression patterns reflect differences in developmental mechanisms within the Anthozoa. BMC Evol Biol. 2008 Nov 12;8:311
  • Technau, U (2008). Evolutionary biology: Small regulatory RNAs pitch in. Nature, 455 (1184 - 1185)
  • Rentzsch F, Fritzenwanker JH, Scholz CB, Technau U (2008). FGF signalling controls formation of the apical sensory organ in the cnidarian Nematostella vectensis. Development, 135(10):1761-9.

 

2007

  • Bielen H, Oberleitner S, Marcellini S, Gee L, Lemaire P, Bode HR, Rupp R and Technau U (2007). Divergent functions of two ancient Hydra Brachyury paralogs suggest specific roles for their activation domains in tissue fate inductions. Development, 23(4187-97).
  • Kraus Y, Fritzenwanker J, Genikhovich G, Technau U (2007). The blastoporal organiser of a sea anemone. Curr Biol. 7(20):R874-6.
  • Fritzenwanker J, Genikhovich G, Kraus Y, Technau U (2007). Early development and axis specification in the sea anemone Nematostella vectensis. Dev Biol. 310(2):264-79.
  • Putnam NH, Srivastava M, Hellsten U, Dirks B, Chapman J, Salamov A, Terry A, Shapiro H, Lindquist E, Kapitonov V, Jurka J, Genikhovich G, Grigoriev I, Lucas S, Steele R, Finnerty J, Technau U, Martindale M, Rokhasr D (2007). Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization. Science, 317(86-94).

 

2006

  • Chourrout D, Delsuc F, Chourrout P, Edvardsen RB, Rentzsch F, Renfer E, Jensen MF, Zhu B, de Jong P, Steeele RE, Technau U (2006). Minimal ProtoHox cluster inferred from bilaterian and cnidarian Hox complements. Nature, 442(7103):684-7.
  • Kraus Y and Technau U (2006). Gastrulation in the sea anemone Nematostella vectensis occurs by invagination and immigration: an ultrastructural study. Dev Genes Evol. (216): 119-132.

 

2005

  • Kusserow A, Pang K, Sturm C, Hrouda M, Lentfer J, Schmidt HA, Technau U, von Haeseler A, Hobmayer B, Martindale MQ and Holstein TW (2005). Unexpected complexity of the Wnt gene family in a sea anemone. Nature 433:156-160.
  • Miller DJ, Ball EE and Technau U (2005). Cnidarians and ancestral genetic complexity in the animal kingdom. Trends Genet. (review) 21(10):536-9.
  • Rentzsch F, Anton R, Saina M, Hammerschmidt M, Holstein TW and Technau U. (2006). Asymmetric expression of BMP antagonists in the sea anemone Nematostella vectensis: implications for the evolution of axial patterning. Dev Biol., 296:375-87.
  • Technau U, Rudd S, Maxwell P, Gordon PMK, Saina M, Grasso LC, Hayward DC, Sensen CW, Holstein TW, Ball EE, Miller DJ (2005). Maintenance of ancestral genetic complexity and non-metazoan genes in two basal cnidarians. Trends Genet. 21(12):633-9.

 

2004

  • Fritzenwanker JH, Saina M and Technau U (2004). Analysis of forkhead and snail expression reveals epithelial-mesenchymal transitions during gastrulation and metamorphosis in Nematostella vectensis. Dev Biol. 275:389-402.
  • Lindgens D, Holstein TW and Technau U (2004). Hyzic, the Hydra homolog of the zic/odd-paired gene, is involved in the early specification of the sensory nematocytes. Development 131:191-201.
  • Technau U, Hobmayer B, Rentzsch F and Holstein TW (2004). Molecular and cellular analysis of de novo pattern formation in Hydra. Function and Regulation of Cellular Systems: Experiments and Models 309-321.

 

2003

  • Marcellini S, Technau U, Smith JC and Lemaire P (2003). Evolution of Brachyury proteins: identification of a novel regulatory domain conserved within Bilateria. Dev Biol. 260:352-361.
  • Scholz C and Technau U (2003). The ancestral role of Brachyury: expression of NemBra1 in the basal cnidarian Nematostella vectensis (Anthozoa). Dev Genes Evol. 212:563-70.
  • Technau U and Scholz C (2003). Origin and evolution of endoderm and mesoderm. Int J Dev Biol. 47:531-539.
  • Technau U, Miller M, Bridge D and Steele R (2003). Arrested apoptosis of nurse cells during Hydra oogenesis and embryogenesis. Dev Biol. 260:191-206.

 

2002

  • Fritzenwanker J and Technau U (2002). Induction of gametogenesis in the basal cnidarian Nematostella vectensis(Anthozoa). Dev Genes Evol. 212:99-103.

 

2001

  • Arendt D, Technau U and Wittbrodt J (2001). Evolution of the bilaterian larval foregut. Nature 409:81-85.
  • Technau U (2001). Brachyury, the blastopore and the evolution of the mesoderm. Bioessays 23:788-94.

 

2000

  • Technau U, Cramer von Laue C, Rentzsch F, Luft S, Hobmayer B, Bode HR and Holstein TW (2000). Parameters of self-organization in Hydra aggregates. Proc Natl Acad Sci. 97:12127-31.
  • Miller M, Technau U, Smith KM and Steele R (2000). Oocyte development in Hydra involves selection from competent precursor cells. Dev Biol. 224:326-338.

 

1999

  • Technau U and Bode HR (1999). HyBra1, a Brachyury homologue, acts during head formation in Hydra. Development 126:999-1010.