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2025
Shah N, Kovalchuk V, Zerlotti R, Cole K, Bazzone A, Sitte HH et al. Rescue of Epilepsy‐Associated Mutations of the Highly Conserved Glycine Residue 443 in the Human GABA Transporter 1. The FASEB Journal. 2025 Juni 15;39(11):e70614. doi: 10.1096/fj.202403159RR
Shah N, Kasture AS, Kovalchuk V, Bjeletic L, Hummel T, Sitte HH et al. Pathogenic variants at the N-terminal arginine residue 44 disrupt human GABA transporter 1 function: insights from Drosophila epilepsy models. Frontiers in Pharmacology. 2025;16:1674737. doi: 10.3389/fphar.2025.1674737
2024
El-Kasaby A, Boytsov D, Kasture A, Krumpl G, Hummel T, Freissmuth M et al. Allosteric Inhibition and Pharmacochaperoning of the Serotonin Transporter by the Antidepressant Drugs Trazodone and Nefazodone. Molecular Pharmacology. 2024 Juli 1;106(1):56-70. doi: 10.1124/molpharm.124.000881
2023
Kasture A, Fischer FP, Kunert L, Burger M, Burgstaller A, El-Kasaby A et al. Drosophila melanogaster as a model for unraveling unique molecular features of epilepsy elicited by human GABA transporter 1 variants. Frontiers in Neuroscience. 2023 Jan. 19;16:1074427. Epub 2023 Jan. 19. doi: 10.3389/fnins.2022.1074427
Bhat S, El-Kasaby A, Kasture A, Boytsov D, Reichelt J, Hummel T et al. A mechanism of uncompetitive inhibition of the serotonin transporter. eLife. 2023 Jan. 17;12:e82641. doi: 10.7554/eLife.82641
2022
Fischer FP, Kasture AS, Hummel T, Sucic S. Molecular and Clinical Repercussions of GABA Transporter 1 Variants Gone Amiss: Links to Epilepsy and Developmental Spectrum Disorders. Frontiers in Molecular Biosciences. 2022 März 2;9:834498. doi: 10.3389/fmolb.2022.834498
2021
Guthrie DA, Kasture A, Cao J, Bonifazi A, El-Kasaby A, Ku T et al. Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters. ACS Pharmacology and Translational Science. 2021;4(2):503-516. doi: 10.1021/acsptsci.0c00102
2020
Pretsch D, Rollinger JM, Schmid A, Genov M, Wöhrer T, Krenn L et al. Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans. Scientific Reports. 2020 Juli 16;10(1):11707. doi: 10.1038/s41598-020-68561-7
Timaeus L, Geid L, Sancer G, Wernet MF, Hummel T. Parallel Visual Pathways with Topographic versus Nontopographic Organization Connect the Drosophila Eyes to the Central Brain. iScience. 2020;23(10):101590. doi: 10.1016/j.isci.2020.101590
2019
Kasture AS, Bartel D, Steinkellner T, Sucic S, Hummel T, Freissmuth M. Distinct contribution of axonal and somatodendritic serotonin transporters in drosophila olfaction. Neuropharmacology. 2019 Dez. 15;161:107564. Epub 2019 März 6. doi: 10.1016/j.neuropharm.2019.03.007
Goyal G, Zierau A, Lattemann M, Bergkirchner B, Javorski D, Kaur R et al. Inter-axonal recognition organizes Drosophila olfactory map formation. Scientific Reports. 2019 Aug. 9;9(1):11554. doi: 10.1038/s41598-019-47924-9
Goyal G, Zheng J, Adam E, Steffes G, Jain M, Klavins K et al. Sphingolipid-dependent Dscam sorting regulates axon segregation. Nature Communications. 2019 Feb. 18;10(1):813. doi: 10.1038/s41467-019-08765-2
2018
Pende M, Becker K, Wanis M, Saghafi S, Kaur R, Hahn C et al. High-resolution ultramicroscopy of the developing and adult nervous system in optically cleared Drosophila melanogaster. Nature Communications. 2018 Nov. 9;9(1):4731. doi: 10.1038/s41467-018-07192-z
Kasture AS, Hummel T, Sucic S, Freissmuth M. Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems. International Journal of Molecular Sciences. 2018 Juni 16;19(6):1788. doi: 10.3390/ijms19061788
2017
Asjad HMM, Kasture A, El-Kasaby A, Sackel M, Hummel T, Freissmuth M et al. Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism. Journal of Biological Chemistry. 2017 Nov. 24;292(47):19250-19265. Epub 2017 Sept. 29. doi: 10.1074/jbc.M117.797092
2016
Kasture A, El-Kasaby A, Szöllősi D, Asjad HMM, Grimm A, Stockner T et al. Functional rescue of a misfolded Drosophila melanogaster dopamine transporter mutant associated with a sleepless phenotype by pharmacological chaperones. Journal of Biological Chemistry. 2016 Sept.;291(40):20876–20890. doi: 10.1074/jbc.M116.737551
Kulkarni A, Ertekin D, Lee CH, Hummel T. Birth order dependent growth cone segregation determines synaptic layer identity in the Drosophila visual system. eLife. 2016 März 17;5(MARCH2016):e13715. doi: 10.7554/eLife.13715
2012
Jafari S, Alkhori L, Schleiffer A, Brochtrup A, Hummel T, Alenius M. Combinatorial activation and repression by seven transcription factors specify Drosophila odorant receptor expression. PLoS Biology. 2012;10(3):e1001280. doi: 10.1371/journal.pbio.1001280
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